Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 1371
interventional 1019
Observational 316
Registry 36

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Behavioral 258
Drug|placebo 164
Other 150
Drug 135
Device 107
Dietary Supplement|placebo 37
Procedure 24
Dietary Supplement 19
Behavioral|Other 12
Drug|Other 12
Behavioral|Device 10
Behavioral|placebo 10
Device|Other 6
Behavioral|Drug|placebo 5
Device|Drug 5
Diagnostic Test 5
Behavioral|Drug 4
Device|placebo 4
Dietary Supplement|Other 4
Drug|Procedure 4
Other|placebo 4
Behavioral|Dietary Supplement|placebo 3
Biological 3
Biological|placebo 3
Combination Product 3
Behavioral|Dietary Supplement 2
Combination Product|placebo 2
Dietary Supplement|Other|placebo 2
Drug|Other|placebo 2
Other|Radiation 2
Behavioral|Dietary Supplement|Other 1
Behavioral|Drug|Other 1
Behavioral|Drug|Other|Radiation 1
Behavioral|Drug|placebo|Procedure 1
Behavioral|Drug|Procedure 1
Behavioral|Procedure 1
Behavioral|Radiation 1
Biological|Other 1
Biological|Other|Procedure 1
Device|Drug|placebo 1
Device|Drug|Radiation 1
Device|Other|Radiation 1
Device|Procedure 1
Diagnostic Test|Procedure 1
Dietary Supplement|Drug 1
Dietary Supplement|Drug|placebo 1
Drug|Radiation 1
Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country Study_Count
United States 461
Canada 70
NA 57
China 53
Taiwan 30
France 28
Germany 24
Italy 23
United Kingdom 22
Spain 20
Korea, Republic of 18
Netherlands 14
Switzerland 13
Brazil 12
Denmark 11
Belgium 8
Israel 8
Norway 8
Singapore 8
Australia 7
Hong Kong 6
Japan 6
Sweden 6
Czechia 5
Turkey 5
Egypt 4
Mexico 4
Portugal 4
Russian Federation 4
United States|Canada 4
Greece 3
Thailand 3
Austria 2
Croatia 2
India 2
Malaysia 2
Pakistan 2
United States|Italy 2
United States|Spain 2
Argentina 1
Australia|Hong Kong 1
Australia|Netherlands 1
Austria|Croatia|Germany|Serbia|Spain 1
Austria|Germany|Israel 1
Belarus|Kazakhstan|Russian Federation 1
Belgium|Canada|Switzerland 1
Belgium|Czechia|Spain|Sweden 1
Belgium|Netherlands 1
Bulgaria|United States|Finland|Germany|Poland|Russian Federation|Ukraine 1
China|Hong Kong 1
Czechia|Germany|Hungary|Netherlands|Spain|United Kingdom 1
Denmark|Italy|Netherlands|Sweden|United Kingdom 1
Estonia|Finland|Germany|Lithuania 1
Estonia|Finland|Germany|Serbia|Slovakia 1
Finland|Netherlands|United Kingdom 1
France|Germany|Greece|Italy|Netherlands|Spain 1
France|Germany|Spain|United Kingdom 1
France|Italy|Spain|Sweden 1
France|Monaco 1
Germany|Ireland|Netherlands 1
Germany|United Kingdom 1
Hungary 1
Ireland 1
Jamaica 1
Lebanon 1
New Zealand 1
Philippines 1
Philippines|Singapore|Vietnam 1
Poland 1
Romania|Spain 1
Serbia 1
Slovakia 1
Slovakia|Taiwan 1
Slovenia 1
Uganda 1
Ukraine 1
United Kingdom|United States|Argentina|Australia|Brazil|Colombia|Italy|Mexico|Poland|Romania|Russian Federation|Ukraine 1
United States|Argentina|Australia|Belgium|Canada|Colombia|Germany|Italy|Mexico|Poland|Romania|Russian Federation|Singapore|Spain|Ukraine|United Kingdom 1
United States|Argentina|Australia|Brazil|Canada|Germany|Mexico|Poland|Russian Federation|Serbia|Singapore|Spain|Ukraine 1
United States|Australia|Canada|France|Mexico|Spain|United Kingdom 1
United States|Australia|France 1
United States|Australia|Spain 1
United States|Austria|Belgium|Canada|France|Germany|Italy|Netherlands|Poland|Portugal|United Kingdom 1
United States|Austria|Canada|Finland|France|Germany|Greece|Hungary|Italy|Japan|Norway|Poland|Spain|United Kingdom 1
United States|Canada|France|Germany|Italy|Spain|Switzerland 1
United States|Canada|United Kingdom 1
United States|China|Israel 1
United States|France|Italy 1
United States|Hungary|Romania|Russian Federation|Serbia|Ukraine 1
United States|India 1
United States|Ireland|Singapore 1
United States|Japan 1
United States|Japan|United Kingdom 1
United States|Russian Federation|United Kingdom 1
United States|Switzerland 1

Sites per Study

Site_count Study_Count
1 772
2 85
3 31
4 21
5 12
6 9
7 2
8 7
9 5
10 2
11 2
12 4
13 6
14 4
15 2
16 4
17 3
18 3
19 1
20 3
23 3
24 4
25 2
26 1
27 1
28 4
29 1
30 2
31 1
37 1
42 1
45 1
47 1
49 1
54 1
57 1
60 1
61 1
64 1
72 1
77 1
92 1
94 1
95 1
104 1
107 1
129 1
145 1
220 1
256 1
262 1

Phase

Phase Study_Count
N/A 639
Phase 2 143
Phase 4 85
Phase 3 58
Phase 1 44
Phase 1/Phase 2 19
Early Phase 1 16
Phase 2/Phase 3 15

Number of Arms

Number_of_Arms Count_of_Studies
1 121
2 619
3 149
4 70
5 11
6 8
7 2
8 2
9 3
10 1
14 1
21 1
NA 31

Number of Updates

Count of Versions Count of Studies
1 117
2 156
3 156
4 144
5 91
6 66
7 66
8 54
9 39
10 22
11 19
12 15
13 15
14 10
15 13
16 4
17 3
18 8
20 5
21 2
22 1
23 1
24 1
25 1
28 1
31 1
39 1
40 1
41 1
46 1
62 1
63 2
82 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 4602 902 5.101996
Contacts/Locations 1987 746 2.663539
Recruitment Status 1169 743 1.573351
None (earliest Version on record) 1019 1019 1.000000
Study Design 828 581 1.425129
Outcome Measures 703 462 1.521645
Eligibility 576 375 1.536000
Arms 509 350 1.454286
Interventions 509 350 1.454286
Study Description 490 348 1.408046
Sponsor/Collaborators 456 309 1.475728
Study Identification 402 265 1.516981
Oversight 297 257 1.155642
Conditions 194 153 1.267974
References 135 100 1.350000
Results 125 125 1.000000
IPDSharing 113 99 1.141414
Results Submission Events 77 77 1.000000
More Information 71 45 1.577778
Documents 45 43 1.046512
Baseline Characteristics 21 17 1.235294
Reported Adverse Events 12 12 1.000000
Participant Flow 8 7 1.142857

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 5.0000 2.0000 5.00000 5.00000 5.0000 10.0000 12.0000 7.0000
1st Qu. 16.0000 40.0000 22.75000 20.00000 48.5000 44.0000 100.0000 40.0000
Median 20.0000 70.0000 33.50000 32.00000 88.0000 70.0000 245.0000 78.0000
Mean 35.9375 211.7355 51.52273 42.47368 134.4126 151.2667 346.2143 230.7529
3rd Qu. 51.0000 150.0000 64.25000 56.50000 172.5000 240.0000 526.0000 222.0000
Max. 143.0000 14641.0000 414.00000 166.00000 1768.0000 513.0000 1584.0000 3300.0000

Trial Group Type

group_type Group_Count
Experimental 1109
Active Comparator 487
Placebo Comparator 298
No Intervention 173
Other 128
Sham Comparator 96
NA 31

Intervention Model

intervention_model Study_Count
Parallel Assignment 745
Single Group Assignment 147
Crossover Assignment 99
Factorial Assignment 21
Sequential Assignment 6
NA 1

Primary Purpose

primary_purpose Study_Count
Treatment 527
Prevention 208
Supportive Care 77
Diagnostic 57
Other 49
Basic Science 48
Health Services Research 21
Screening 16
NA 14
Device Feasibility 2

Observational Studies

Studies by Country

Country Study_Count
United States 107
China 27
NA 18
Canada 17
Germany 15
Denmark 14
France 11
Italy 11
Switzerland 9
Egypt 8
United Kingdom 8
Norway 7
Israel 5
Belgium 4
Korea, Republic of 4
Netherlands 4
Spain 4
Austria 3
Hong Kong 3
Singapore 3
Sweden 3
Taiwan 3
Turkey 3
United States|Canada 3
Finland 2
Indonesia 2
Poland 2
Australia 1
Australia|Germany|Spain|Sweden 1
Canada|Netherlands|Sweden 1
Cyprus 1
France|Italy 1
France|Japan 1
Iceland 1
Lithuania 1
Malaysia 1
Portugal 1
Russian Federation 1
Tanzania 1
Thailand 1
United States|Argentina|Australia|Austria|Belgium|Canada|Czech Republic|Finland|France|Germany|Israel|Netherlands|Poland|Spain|Sweden|United Kingdom 1
United States|Puerto Rico 1
United States|Spain 1

Sites per Study

Site_count Study_Count
1 264
2 23
3 5
4 4
5 3
6 2
7 1
8 1
9 3
12 2
16 1
19 2
25 1
55 1
58 1
59 1
145 1

Number of Updates

Count of Versions Count of Studies
1 46
2 62
3 47
4 47
5 33
6 22
7 11
8 12
9 6
10 7
11 3
12 4
13 3
14 2
16 1
17 1
22 1
23 1
27 1
48 1
59 1
80 1
88 1
120 1
676 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 2095 270 7.759259
Contacts/Locations 566 200 2.830000
None (earliest Version on record) 316 316 1.000000
Recruitment Status 295 196 1.505102
Study Design 219 158 1.386076
Outcome Measures 158 115 1.373913
Eligibility 139 89 1.561798
Study Description 123 86 1.430233
Sponsor/Collaborators 113 85 1.329412
Study Identification 112 79 1.417722
Groups 102 68 1.500000
Interventions 102 68 1.500000
Oversight 74 66 1.121212
Conditions 54 41 1.317073
References 48 31 1.548387
IPDSharing 21 20 1.050000
Results 10 10 1.000000
More Information 9 4 2.250000
Results Submission Events 6 6 1.000000
Documents 5 3 1.666667
Reported Adverse Events 2 1 2.000000
Baseline Characteristics 1 1 1.000000
Participant Flow 1 1 1.000000

Enrollment Metrics

Measure Observational
Min 6.0000
1st Qu 69.0000
Median 150.0000
Mean 629.8354
3rd Qu 400.0000
Max 25240.0000

Observation Model

observational_model Study_Count
Cohort 184
Case-Control 54
Case-Only 28
Case Control 18
Other 18
NA 5
Case-Crossover 4
Ecologic or Community 4
Natural History 1

Time Perspective

time_perspective Study_Count
Prospective 254
Cross-Sectional 39
Retrospective 16
Other 5
Longitudinal, Prospective 1
NA 1

Registries

Studies by Country

Country Study_Count
China 9
United States 5
Hong Kong 3
Belgium 2
Egypt 2
Germany 2
NA 2
Taiwan 2
Turkey 2
Canada 1
Denmark 1
Ecuador 1
Finland 1
France 1
Korea, Republic of 1
Spain 1

Sites per Study

Site_count Study_Count
1 31
2 2
3 1
28 1
65 1

Number of Updates

Count of Versions Count of Studies
1 11
2 6
3 6
4 6
5 4
6 1
7 1
8 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 70 25 2.800000
None (earliest Version on record) 36 36 1.000000
Contacts/Locations 24 16 1.500000
Recruitment Status 20 17 1.176471
Outcome Measures 10 9 1.111111
Study Design 10 10 1.000000
Study Description 9 8 1.125000
Groups 7 7 1.000000
Interventions 7 7 1.000000
Oversight 6 6 1.000000
Eligibility 5 5 1.000000
Study Identification 5 5 1.000000
Sponsor/Collaborators 3 3 1.000000
Conditions 1 1 1.000000
Documents 1 1 1.000000
IPDSharing 1 1 1.000000

Enrollment Metrics

Measure Registries
Min 30.000
1st Qu 100.000
Median 500.000
Mean 1856.667
3rd Qu 973.750
Max 25000.000

Registry Model

observational_model Study_Count
Cohort 20
Case-Control 9
Case-Only 4
Other 3

Time Perspective

time_perspective Study_Count
Prospective 28
Cross-Sectional 7
Other 1

Follow-up

target_duration Study_Count
5 Years 5
1 Day 4
2 Years 4
6 Months 3
1 Month 2
12 Months 2
2 Months 2
3 Years 2
1 Year 1
10 Years 1
18 Months 1
2 Days 1
2 Weeks 1
20 Years 1
24 Months 1
25 Years 1
3 Months 1
36 Months 1
4 Weeks 1
9 Months 1